Copy number variants and placental abnormalities in stillborn fetuses: A secondary analysis of the Stillbirth Collaborative Research Network study.

Tsegaselassie WorkalemahuSusan DaltonAmanda AllshouseAndrew Z CareyJessica M PageNathan R BlueVanessa ThorstenRobert L GoldenbergHalit PinarUma M ReddyRobert M Silver

Published in: BJOG : an international journal of obstetrics and gynaecology (2022)

Abnormal placental/fetal CNVs were associated with maternal vascular PPLs in stillbirth cases. The findings may provide insight into the mechanisms of specific genetic abnormalities associated with placental dysfunction and stillbirth.

Keyphrases

copy number
mitochondrial dna
genome wide
dna methylation
oxidative stress
gene expression
pregnant women
physical activity
pregnancy outcomes
weight loss