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Correlation between plasma ccfDNA, mtDNA changes, CTCs, and epithelial-mesenchymal transition in breast cancer patients undergoing NACT.

Betül Çelikİrem Peker EyüboğluSinan KocaMustafa Ümit UğurluÖzkan AlanGokce Gullu AmuranTuğba Akın TelliPerran Fulden YumukMustafa Akkiprik
Published in: Turkish journal of medical sciences (2024)
This study represents the first comprehensive investigation of plasma ccfDNA levels, mtDNAcn, and integrities collectively. Furthermore, it is the first study to explore the relationship between these markers and CTCs, cancer stem cell markers, treatment response, and metastatic status. Our findings suggest that plasma ccfDNA and mtDNA may serve as potential biomarkers for assessing chemotherapy response and can be employed alone or in combination with other biomarkers to monitor treatment efficacy in breast cancer patients.
Keyphrases
  • epithelial mesenchymal transition
  • patients undergoing
  • circulating tumor cells
  • small cell lung cancer
  • cancer stem cells
  • copy number
  • mitochondrial dna
  • transforming growth factor
  • combination therapy