[Possible applications of saliva for the diagnosis of cancer.]

Use of saliva in the clinical laboratory diagnosis is promising, and non-invasive, simple and inexpensive method for the detection of diseases. Integration of complex techniques, including genomic research, epigenome, transcriptome, proteome, metabolome and microbiome, can detect and quantify the number of biomarkers in saliva. Research saliva relates to non-invasive techniques and conducted to evaluate the age and physiological status, detection of somatic diseases, diseases of the salivary glands and oral tissues, genetic markers, drug monitoring, and others. In this review, recent data on the use of saliva to diagnose cancers examined.