Structural basis for inhibition of coagulation factor VIII reveals a shared antigenic hotspot on the C1 domain.
Kenneth C ChildersBen CowperJordan D VaughanJuliet R McGillOmar DavulcuPete LollarChristopher B DoeringCarmen H CoxonPaul C SpiegelPublished in: Journal of thrombosis and haemostasis : JTH (2024)
These results describe an antigenic "hotspot" on the FVIII C1 domain and provide a structural basis for engineering FVIII replacement therapeutics with reduced antigenicity.
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