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Effect of cyclical intermittent hypoxia on Ad5CMVCre induced solitary lung cancer progression and spontaneous metastases in the KrasG12D+; p53fl/fl; myristolated p110fl/fl ROSA-gfp mouse.

Xiaofeng GuoYan LiuJessica L KimEmily Y KimEdison Q KimAlexandria JansenKatherine LiMay ChanBrendan T KeenanJose Conejo-GarciaDiane C Lim
Published in: PloS one (2019)
Using a GEM mouse model of metastatic lung cancer, we report that male mice with solitary lung cancer have accelerated malignant progression and increased variability in tumor growth when exposed to cyclical intermittent hypoxia. Our results indicate that cyclical intermittent hypoxia is a pathogenic factor in non-small cell lung cancer that promotes the more rapid growth of developing tumors.
Keyphrases
  • mouse model
  • high intensity
  • endothelial cells
  • high glucose
  • squamous cell carcinoma
  • small cell lung cancer
  • diabetic rats
  • oxidative stress
  • drug induced
  • quantum dots