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Breakthrough SARS-CoV-2 infections after vaccination: a critical review.

Zeinab Mohseni AfsharMohammad BararyRezvan HosseinzadehAmirmasoud AlijanpourDariush HosseinzadehSoheil EbrahimpourKosar NazaryTerence T SioMark J M SullmanKristin V Carson-ChahhoudArefeh Babazadeh
Published in: Human vaccines & immunotherapeutics (2022)
At the beginning of the current pandemic, it was believed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection would induce lifelong immunity and that reinfections would be unlikely. However, after several cases of reinfection were documented in previously infected patients, this was understood to be a false assumption, and this waning humoral immunity has raised significant concerns. Accordingly, long-term and durable vaccine-induced antibody protection against infection have also become a challenge, as several breakthroughs of COVID-19 infection have been identified in individuals who were fully vaccinated. This review discusses the current evidence on breakthrough COVID-19 infections occurring after vaccination.
Keyphrases
  • respiratory syndrome coronavirus
  • sars cov
  • coronavirus disease
  • immune response
  • high glucose
  • diabetic rats