Rare Variants in Genes Encoding Subunits of the Epithelial Na + Channel Are Associated With Blood Pressure and Kidney Function.
Brandon M BlobnerAnnet KiraboOssama B KashlanShaohu ShengDonna K ArnettLewis C BeckerEric BoerwinkleJenna C CarlsonYan GaoRichard A GibbsJiang HeMarguerite R IrvinSharon L R KardiaTanika N KellyCharles KooperbergStephen T McGarveyVipin K MenonMay E MontasserTake NaseriSusan RedlineAlexander P ReinerMuagututi'a S ReupenaJennifer A SmithXiao SunR Dhananjay VaidyaKarine A Viaud-MartinezDaniel E WeeksLisa R YanekXiaofeng Zhunull nullRyan L MinsterThomas R KleymanPublished in: Hypertension (Dallas, Tex. : 1979) (2022)
Our results suggest that variants in extrarenal ENaCs, in addition to ENaCs expressed in kidneys, influence blood pressure and kidney function.