Organophosphate pesticide-induced toxicity through DNA damage and DNA repair mechanisms.
Joyline PrathikshaRekha K NarasimhamurthyHerman Sunil DsouzaKamalesh Dattaram MumbrekarPublished in: Molecular biology reports (2023)
Organophosphate pesticides (OPs) are widely used in agriculture, healthcare, and other industries due to their ability to kill pests. However, OPs can also have genotoxic effects on humans who are exposed to them. This review summarizes the research on DNA damage caused by OPs, the mechanisms behind this damage, and the resulting cellular effects. Even at low doses, OPs have been shown to damage DNA and cause cellular dysfunction. Common phenomena seen in cells that are exposed to OPs include the formation of DNA adducts and lesions, single-strand and double-strand DNA breaks, and DNA and protein inter and intra-cross-links. The present review will aid in comprehending the extent of genetic damage and the impact on DNA repair pathways caused by acute or chronic exposure to OPs. Additionally, understanding the mechanisms of the effects of OPs will aid in correlating them with various diseases, including cancer, Alzheimer's, and Parkinson's disease. Overall, knowledge of the potential adverse effects of different OPs will help in monitoring the health complications they may cause.
Keyphrases
- dna repair
- dna damage
- oxidative stress
- healthcare
- circulating tumor
- cell free
- single molecule
- induced apoptosis
- dna damage response
- diabetic rats
- mental health
- nucleic acid
- public health
- papillary thyroid
- climate change
- respiratory failure
- risk factors
- lymph node metastasis
- liver failure
- health information
- circulating tumor cells
- cell death
- high glucose
- endothelial cells
- amino acid
- emergency department
- electronic health record
- affordable care act