Efficacy and safety of radiotherapy combined with anti-angiogenic therapy and immune checkpoint inhibitors in MSS/pMMR metastatic colorectal cancer.

Menglan ZhaiZixuan ZhangHaihong WangJinghua RenSheng ZhangMingjie LiLichao LiuLisha LiLan ZhangXin LiTao Zhang Zhenyu Lin

Published in: Cancer medicine (2023)

Compared with TT + IT, RT combined with TT + IT improved survival outcomes in MSS/pMMR mCRC patients, with manageable toxicity. RT sequential/simultaneous TT + IT treatment is expected to be the optimal strategy for MSS/PMMR mCRC.

Keyphrases

metastatic colorectal cancer
early stage
radiation therapy
oxidative stress
locally advanced
radiation induced
stem cells
rectal cancer