The Effect of Mesenchymal Stem Cell-Derived Exosomes and miR17-5p Inhibitor on Multicellular Liver Fibrosis Microtissues.

Farnaz Sani Mina Soufizomorrod Negar Azarpira Masoud Soleimani

Published in: Stem cells international (2023)

Our findings indicated that anti-miR17-5p and MSC-EXO might be promising therapeutic options for treating liver fibrosis. Furthermore, EXO + anti-miR had the best effects on boosting the fibrotic markers. Therefore, we propose this novel MLM model to understand fibrosis mechanisms better and develop new drugs.

Keyphrases

liver fibrosis
mesenchymal stem cells
cell proliferation
long non coding rna
stem cells
bone marrow
cell therapy
drug induced