FGF21 serum levels are related to insulin resistance, metabolic changes and obesity in Mexican people living with HIV (PLWH).

Arguiñe Ivonne Urraza-RobledoMarta GiraltFaviel Francisco González-GalarzaFrancesc VillarroyaAlberto Alejandro Miranda PérezPablo Ruiz FloresMaría Elena Gutiérrez PérezPeré DomingoFrancisco Carlos López Márquez

Published in: PloS one (2021)

Insulin resistance and FGF21 elevations were observed in overweight-obese PLWH. FGF21 elevation could be viewed as a compensation mechanism as, in the control group, FGF21 correlations appeared to be confined to weight and waist circumference. This can be explained based on the action of FGF21 promoting the uptake of glucose in adipose tissue. In PLWH, FGF21 was low, possibly as a result of a change in adiposity leading to a metabolic disruption.

Keyphrases

insulin resistance
adipose tissue
metabolic syndrome
weight loss
body mass index
high fat diet
type diabetes
weight gain
high fat diet induced
polycystic ovary syndrome
skeletal muscle
physical activity
bariatric surgery
obese patients
blood pressure