Invasive FoxM1 phosphorylated by PLK1 induces the polarization of tumor-associated macrophages to promote immune escape and metastasis, amplified by IFITM1.
Rong XuYoung-Joo LeeChang-Hyeon KimGa-Hong MinYeo-Bin KimJung-Won ParkDae-Hoon KimJung-Hyun KimHyungshin YimPublished in: Journal of experimental & clinical cancer research : CR (2023)
FoxM1-based therapy would be a potential therapeutic strategy for LUAD to reduce TAM polarization, immune escape, and metastasis, since FoxM1 functions as a genetic reprogramming factor reinforcing LUAD malignancy in the TME.