Lymphomatoid papulosis mimicking relapsed angioimmunoblastic T-cell lymphoma on histology: the importance of clinicopathological correlation.
Ayoma D AttygalleDorte WrenRachel DobsonKatherine M VroobelBhupinder SharmaSimon O'ConnorAndrew C WotherspoonMing-Qing DuDavid CunninghamPublished in: Histopathology (2020)
Angioimmunoblastic T-cell lymphoma (AITL) is one of the commonest subtypes of peripheral T-cell lymphoma (PTCL) world-wide and the most common non-cutaneous PTCL in Western Europe. Despite aggressive chemotherapy +/- consolidation autologous stem cell transplant relapse occurs in >50% of cases which is either treated aggressively with high dose chemotherapy followed by allogeneic transplant or with therapy aimed at producing prolonged disease control.1 Biopsy of relapsed disease is essential as a subset may be complicated by a B-cell (often EBV+) lymphoproliferation. Histological progression may occur with a monomorphic/'tumour cell rich' appearance rather than the polymorphous appearance seen in typical AITL.2.
Keyphrases
- high dose
- diffuse large b cell lymphoma
- stem cells
- acute lymphoblastic leukemia
- stem cell transplantation
- acute myeloid leukemia
- cell therapy
- bone marrow
- hodgkin lymphoma
- multiple myeloma
- locally advanced
- epstein barr virus
- chemotherapy induced
- low dose
- single cell
- south africa
- squamous cell carcinoma
- rectal cancer
- hematopoietic stem cell
- replacement therapy