Role of NINJ1 in Gout Flare and Potential as a Drug Target.

Hongliang ZhangJie GaoWenxiang FangYujie TangXuan FangTeng-Chuan Jin Jin-Hui Tao

Published in: Journal of inflammation research (2022)

These results support the notion of a pathogenic role of NINJ1 introduced PMR in gout and provide a detailed mechanism for gout pathogenesis involving inflammatory cell death and DAMPs release introduced by IL-1β. In addition, targeting NINJ1 might be a potential therapeutic approach for gout.

Keyphrases

uric acid
cell death
metabolic syndrome
oxidative stress
cancer therapy
emergency department
climate change
human health