Immunologically programming the tumor microenvironment induces the pattern recognition receptor NLRC4-dependent antitumor immunity.

Xiaofei YuWenjie LiuShixian ChenXueqian ChengPatrick A PaezTuanwei SunFang YuanChunyan WeiJoseph W LandryAndrew S PoklepovicHarry D BearJohn R SubjeckElizabeth RepaskyChunqing GuoXiang-Yang Wang

Published in: Journal for immunotherapy of cancer (2021)

Our results elucidate a novel immune-potentiating activity of Flagrp170 via engaging the innate pattern recognition receptor NLRC4, and support its potential clinical use to reshape cancer immune phenotype for overcoming therapeutic resistance.

Keyphrases

immune response
papillary thyroid
squamous cell
binding protein
squamous cell carcinoma
childhood cancer