Claudin-12 Deficiency Inhibits Tumor Growth by Impairing Transendothelial Migration of Myeloid-Derived Suppressor Cells.

Hong CaoChen NiLe HanRuoqi WangRosel BlasigReiner HaseloffYue QinJie LanXiaohan LouPan MaXiaohan YaoLinlin WangFei WangLinyu ZhuNingjing LeiIngolf E BlasigZhihai Qin

Published in: Cancer research (2022)

Claudin-12-mediated homotypic interactions are critical for migration of myeloid-derived suppressor cells across vascular walls into tumor tissue, providing a potential therapeutic approach to overcome cancer immunosuppression.

Keyphrases

induced apoptosis
cell cycle arrest
papillary thyroid
cell death
squamous cell carcinoma
cell proliferation
young adults
squamous cell
lymph node metastasis