Proinflammatory Cytokine Environments Can Drive Interleukin-17 Overexpression by γ/δ T Cells in Systemic Juvenile Idiopathic Arthritis.

Christoph KesselKatrin LippitzToni Weinhage Claas H HinzeHelmut WittkowskiDirk HolzingerNdate FallAlexei A GromNiklas GruenDirk Foell

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2017)

A systemic JIA cytokine environment may prime γ/δ T cells in particular for IL-17A overexpression. Thus, our observations in systemic JIA patients strongly support a pathophysiologic role of these cells, as proposed by the recent murine model.

Keyphrases

juvenile idiopathic arthritis
end stage renal disease
cell proliferation
disease activity
chronic kidney disease
ejection fraction
transcription factor
prognostic factors
systemic lupus erythematosus
rheumatoid arthritis
cell cycle arrest
patient reported outcomes