Genetic predisposition to hematologic malignancies: management and surveillance.
Lucy A GodleyAkiko ShimamuraPublished in: Blood (2017)
As individuals with germ line predisposition to hematologic malignancies are diagnosed with increasing frequency, the need for clinical surveillance has become apparent. Unfortunately, few prospective data are available, so recommendations are based on collective experience and expert consensus. There is general agreement to advocate for expert consultation or referral of patients to centers with expertise in these syndromes, since presentations and disease progression can be subtle, and treatment strategies must be tailored. Here, we summarize and integrate expert consensus recommendations and medical management considerations for the patient newly diagnosed with a leukemia predisposition disorder. Indications to consider additional studies and referral for allogeneic stem cell transplantation are also discussed.
Keyphrases
- stem cell transplantation
- newly diagnosed
- high dose
- public health
- clinical practice
- primary care
- bone marrow
- ejection fraction
- healthcare
- case report
- acute myeloid leukemia
- genome wide
- prognostic factors
- palliative care
- dna methylation
- smoking cessation
- big data
- artificial intelligence
- patient reported outcomes
- machine learning
- patient reported
- case control