The intact nephron hypothesis as a model for renal drug handling.
Sudeep PradhanStephen B DuffullRobert J WalkerDaniel F B WrightPublished in: European journal of clinical pharmacology (2018)
Our results suggest that the INH may not be a suitable general model for renal drug handling, particularly for drugs that are eliminated by tubular mechanisms. Further studies to assess the clinical importance of a non-linear relationship between drug clearance and GFR are warranted.
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