Ancestry specific distribution of LPA Kringle IV-Type-2 genetic variants highlight associations to apo(a) copy number, glucose, and hypertension.

Yihao Li Florian Kronenberg Stefan CoassinBadri VardarajanGissette Reyes-Soffer

Published in: medRxiv : the preprint server for health sciences (2024)

KIV-2 variants found in three ancestry groups, including data on Caribbean Hispanics, show strong positive associations to hypertension and negative associations to glucose levels. Further characterization of these variants and identifying links to disease can help precision medicine efforts to understand disease mechanisms in all populations.

Keyphrases

copy number
mitochondrial dna
blood pressure
genome wide
dna methylation
blood glucose
electronic health record
gene expression
metabolic syndrome
quality improvement
machine learning
data analysis
deep learning