A novel synthesis, X-ray analysis and computational studies of (Z)-ethyl 2-((Z)-5-((dimethylamino)methylene)- 4-oxo-3-phenylthiazolidin-2-ylidene)acetate as a potential anticancer agent.
Yahia Nasser MabkhotMohammed M AlharbiSalim S Al-ShowimanSaied M SolimanNabila A KhederWolfgang FreyAbdulrhman AsayariAbdullatif Bin MuhsinahH AlgarniPublished in: BMC chemistry (2019)
An unexpected synthesis of (Z)-ethyl 2-((Z)-5-((dimethylamino)methylene)-4-oxo-3-phenylthiazolidin-2-ylidene)acetate via deacetylation mechanism. The structure was established using X-ray and spectral analysis. The geometric parameters, and NMR spectra were discussed. The synthesized compounds showed moderate anticancer activity.