Screening siRNAs against host glycosylation pathways to develop novel antiviral agents against hepatitis B virus.

Kiyoaki ItoKiyohiko AngataAtsushi KunoAkinori OkumuraKazumasa SakamotoRieko InoueNaoko MoritaKoichi WatashiTakaji WakitaYasuhito TanakaMasaya SugiyamaMasashi MizokamiMasashi YonedaHisashi Narimatsu

Published in: Hepatology research : the official journal of the Japan Society of Hepatology (2020)

These results showed that knocking down the ST8SIA3 and GALNT7 glycogenes inhibited HBsAg and HBV DNA secretion in HepG2.2.15.7 cells, indicating that the host glycosylation pathway is important for the HBV life cycle and could be a potential target for the development of novel anti-HBV agents.

Keyphrases

hepatitis b virus
life cycle
liver failure
circulating tumor
cell free
nucleic acid