A novel delivery nanobiotechnology: engineered miR-181b exosomes improved osteointegration by regulating macrophage polarization.

Wei LiuMuyu YuFeng ChenLongqing WangCheng YeQing ChenQi ZhuDong XieMingzhe ShaoLili Yang

Published in: Journal of nanobiotechnology (2021)

Exo-181b could suppress inflammatory response by promoting M2 polarization via activating PRKCD/AKT signaling pathway, which further promoting osteogenesis in vitro and promote osteointegration in vivo.

Keyphrases

signaling pathway
inflammatory response
pi k akt
induced apoptosis
epithelial mesenchymal transition
mesenchymal stem cells
stem cells
lipopolysaccharide induced
lps induced
toll like receptor
bone marrow