Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation.

Marion OuidirPauline MendolaGermaine M Buck LouisKurunthachalam KannanCuilin ZhangFasil Tekola-Ayele

Published in: Clinical epigenetics (2020)

DNA methylation changes in the placenta were significantly associated with maternal plasma POPs concentration. The findings suggest that placental DNA methylation and gene expression mechanism may be involved in the prenatal toxicity of POPs and their association with neonatal anthropometry measures.

Keyphrases

dna methylation
gene expression
genome wide
birth weight
pregnancy outcomes
pregnant women
copy number
oxidative stress