Hepatic and adipose tissue transcriptome analysis highlights a commonly deregulated autophagic pathway in severe MASLD.

Marica MeroniEmilia De CaroFederica ChiapporiMiriam LongoErika PaoliniEttore MoscaIvan MerelliRosa LombardiSara BadialiMarco MaggioniAlessandro OrroAlessandra MezzelaniLuca ValentiAnna Ludovica FracanzaniPaola Dongiovanni

Published in: Obesity (Silver Spring, Md.) (2024)

By comparing the hepatic and VAT transcriptome during MASLD, we refined the concept by which CTSD may represent a potential biomarker of severe disease.

Keyphrases

adipose tissue
early onset
cell death
gene expression
insulin resistance
single cell
rna seq
genome wide
drug induced
type diabetes
dna methylation