An accurate and dual-effective body slimming method through a soluble microneedle patch with variable temperature.
Haichuan PengYan ZhouChuxi ZhangManyu WangSiyu ZhaoYingying XuWei ZhangHongbo XinXiaolei WangPublished in: Journal of materials chemistry. B (2021)
Obesity is a chronic and recurrent disease with potential risks. Traditional weight-loss methods (like exercises, surgeries, oral drugs, etc.) have shown different side effects. In this experiment, the microneedle (MN) patch was selected as the drug carrier of the weight-loss drug Rosiglitazone (Rosi). Besides, melanin was added to enhance the photo-thermal effect and accelerate the release of drugs to the target fat region under near-infrared (NIR) light. Afterwards, with exterior cold stimulation, the significant and accurate effect of body slimming could be achieved. This combination of soluble MN patches and variable temperatures provides an attractive nonsurgical method for future accurate body slimming management.
Keyphrases
- weight loss
- bariatric surgery
- roux en y gastric bypass
- high resolution
- gastric bypass
- drug induced
- weight gain
- human health
- metabolic syndrome
- adipose tissue
- insulin resistance
- adverse drug
- glycemic control
- physical activity
- risk assessment
- resistance training
- drug delivery
- current status
- mass spectrometry
- transition metal
- ionic liquid
- high intensity