Glial Cell-Mediated Neuroinflammation in Alzheimer's Disease.
Nour F Al-GhraiybahJunwei WangAmer E AlkhalifaAndrew B RobertsRuchika RajEuitaek YangAmal KaddoumiPublished in: International journal of molecular sciences (2022)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder; it is the most common cause of dementia and has no treatment. It is characterized by two pathological hallmarks, the extracellular deposits of amyloid beta (Aβ) and the intraneuronal deposits of Neurofibrillary tangles (NFTs). Yet, those two hallmarks do not explain the full pathology seen with AD, suggesting the involvement of other mechanisms. Neuroinflammation could offer another explanation for the progression of the disease. This review provides an overview of recent advances on the role of the immune cells' microglia and astrocytes in neuroinflammation. In AD, microglia and astrocytes become reactive by several mechanisms leading to the release of proinflammatory cytokines that cause further neuronal damage. We then provide updates on neuroinflammation diagnostic markers and investigational therapeutics currently in clinical trials to target neuroinflammation.
Keyphrases
- lipopolysaccharide induced
- cognitive impairment
- lps induced
- traumatic brain injury
- cerebral ischemia
- inflammatory response
- clinical trial
- neuropathic pain
- cognitive decline
- multiple sclerosis
- oxidative stress
- mild cognitive impairment
- stem cells
- blood brain barrier
- cell therapy
- spinal cord
- spinal cord injury
- study protocol