DPP4 Promotes Human Endothelial Cell Senescence and Dysfunction via the PAR2-COX-2-TP Axis and NLRP3 Inflammasome Activation.

Inés ValenciaSusana VallejoPilar DongilAlejandra RomeroÁlvaro San Hipólito-LuengoLicia ShamoonMaría PosadaDamián García-OlmoRaffaelle CarraroJorge D ErusalimskyTania Romacho Concepción Peiró Carlos F Sánchez-Ferrer

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

These results reveal sDPP4 as a relevant mediator in early vascular aging and highlight its capacity activating main proinflammatory mediators in the endothelium that might be pharmacologically tackled.

Keyphrases

endothelial cells
nlrp inflammasome
high glucose
vascular endothelial growth factor
signaling pathway
nitric oxide
oxidative stress
genome wide
single cell
dna damage
induced pluripotent stem cells
dna methylation
gene expression