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Quantitative analysis of cryptic splicing associated with TDP-43 depletion.

Jack HumphreyWarren EmmettPietro FrattaAdrian M IsaacsVincent Plagnol
Published in: BMC medical genomics (2017)
Our quantitative analysis pipeline confirms the presence of cryptic exons during the depletion of TDP-43 but not FUS providing new insight into to RNA-processing dysfunction as a cause or consequence in ALS/FTD.
Keyphrases
  • amyotrophic lateral sclerosis
  • oxidative stress