The molecular classification of cancer-associated fibroblasts on a pan-cancer single-cell transcriptional atlas.

Bonan ChenWai Nok ChanFuda XieChun Wai MuiXiaoli LiuAlvin H K CheungRaymond W M LungChit ChowZhenhua ZhangCanbin FangPeiyao YuShihua ShiShikun ZhouGuoming ChenZhangding WangShouyu WangXiaofan DingBing HuangLi LiangYujuan DongChi Chun WongWilliam K K WuAlfred S L ChengNathalie WongShuang YuKwok Wai LoGary M K TseWei KangKa Fai To

Published in: Clinical and translational medicine (2023)

Collectively, the various subtypes of CAFs, particularly matCAF, are crucial in the initiation and progression of cancer. Focusing therapeutic strategies on targeting matCAF in solid tumours holds significant potential for cancer treatment.

Keyphrases

single cell
papillary thyroid
squamous cell
machine learning
rna seq
deep learning
transcription factor
lymph node metastasis
high throughput
oxidative stress
cancer therapy
climate change
extracellular matrix
heat shock