Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach.

Cheng PengAndres CardenasSheryl L Rifas-ShimanMarie-France HivertDiane R GoldThomas A Platts-MillsXihong LinEmily OkenAndrea A BaccarelliAugusto A LitonjuaDawn L DeMeo

Published in: Clinical epigenetics (2018)

This study identified fetally programmed and mid-childhood methylation signals associated with mid-childhood IgE. Epigenetic priming during fetal development and early childhood likely plays an important role in IgE-mediated type-I hypersensitivity.

Keyphrases

dna methylation
gene expression
young adults
genome wide
early life
childhood cancer