Acute alcohol withdrawal and recovery in men lead to profound changes in DNA methylation profiles: a longitudinal clinical study.
Stephanie-H WittJosef FrankUlrich FrischknechtJens TreutleinFabian StreitJerome C FooLea SirignanoHelene DukalFranziska DegenhardtAnne KoopmannSabine HoffmannGabi KollerOliver PogarellUlrich W PreussPeter ZillKristina AdorjanThomas G SchulzeMarkus NöthenRainer SpanagelFalk KieferMarcella RietschelPublished in: Addiction (Abingdon, England) (2020)
Acute alcohol withdrawal in severely dependent male patients appears to be associated with extensive changes in epigenome-wide methylation patterns. In particular, genes involved in immune system response seem to be affected by this condition.
Keyphrases
- dna methylation
- liver failure
- end stage renal disease
- respiratory failure
- genome wide
- ejection fraction
- chronic kidney disease
- gene expression
- newly diagnosed
- drug induced
- aortic dissection
- peritoneal dialysis
- prognostic factors
- alcohol consumption
- intensive care unit
- hepatitis b virus
- autism spectrum disorder
- intellectual disability
- middle aged
- patient reported outcomes
- extracorporeal membrane oxygenation
- copy number
- patient reported