Sequence not salvage.
Douglas W SborovGliceida Galarza FortunaPatrick J HaydenPublished in: British journal of haematology (2024)
Chimeric antigen receptor T-cell (CAR-T) therapy for the treatment of multiple myeloma (MM) has fundamentally changed the relapsed and refractory therapeutic landscape, but the disease remains incurable. Two CAR-T products, idecabtagene vicleucel (ide-cel; Abecma) and ciltacabtagene autoleucel (cilta-cel, Carvykti), have been FDA- and EMA-approved for the treatment of relapsed/refractory MM (RRMM); both target B-cell maturation antigen (BCMA), a surface glycoprotein highly expressed on MM cells. Despite deep and durable responses following CAR-T therapy, most patients will need subsequent treatment, and the optimal next-line therapy is presently unclear. Commentary on: Liu et al. Outcomes in patients with multiple myeloma receiving salvage treatment after BCMA-specific CAR-T therapy: A retrospective analysis of LEGEND-2. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19340.
Keyphrases
- multiple myeloma
- acute myeloid leukemia
- acute lymphoblastic leukemia
- end stage renal disease
- healthcare
- chronic kidney disease
- newly diagnosed
- ejection fraction
- induced apoptosis
- hodgkin lymphoma
- replacement therapy
- prognostic factors
- single cell
- skeletal muscle
- bone marrow
- insulin resistance
- cell proliferation
- endoplasmic reticulum stress
- patient reported