Adeno-associated virus-vectored erythropoietin gene therapy for anemia in cats with chronic kidney disease.

Shelly L Vaden Allison R Kendall Jonathan Daniel FosterHeidi L NewJane S EaglesonJacky L MayAnne M TraasMatthew J WilsonBeth H McIntyreChristian J HindererLauren K OlenickJames M Wilson

Published in: Journal of veterinary internal medicine (2023)

Results of this study suggest that SB-001 therapy represents a suitable single injection treatment that can address nonregenerative anemia in cats with CKD. It was generally well tolerated; however, hypertension and encephalopathy developed in some cats as previously described in association with erythropoiesis-stimulating agent therapy.

Keyphrases

chronic kidney disease
end stage renal disease
blood pressure
early onset
stem cells
copy number
genome wide
ultrasound guided