Apixaban in a porcine model of mechanical valve thrombosis in pulmonary position-a pilot study.
Lucas Van HoofIsabelle TruyersHadewych Van HauwermeirenBram NachtergaeleTom LangenaekenMarc JacqueminFilip R RegaPeter VerhammeBart MeurisPublished in: Interactive cardiovascular and thoracic surgery (2022)
The pulmonary position seems to be an aggressive model for mechanical valve thrombosis in pigs. Apixaban has the potential to prevent valve thrombosis, even in these thrombogenic conditions. Detailed pharmacokinetic studies are needed to determine the ideal apixaban dosage for future experiments and to enable extrapolation to the clinical situation.