Sarglamides A-E, Indolidinoid-Monoterpenoid Hybrids with Anti-neuroinflammatory Activity from a Sarcandra Species.
Bin ZhouQi GongYan FuJun-Su ZhouHai Yan ZhangJian-Min YuePublished in: Organic letters (2023)
Sarglamides A-E ( 1 - 5 ), representing the first example of heterodimers of a trans - N -cinnamoylindolidinoid and α-phelladrene derivatives, were isolated from Sarcandra glabra subsp. brachystachys . Particularly, compounds 4 and 5 possess unprecedented cagelike 6/6/5/6/5- and 6/6/6/6/5-fused pentacyclic scaffolds, respectively. Their structures were established by spectroscopic analysis, X-ray crystallography, quantum-chemical calculations, and chemical conversions. Plausible biosynthetic pathways of 1 - 5 involving the coisolated enantiomers 6a and 6b were proposed. Compounds 3 - 7 showed inhibitory activity against lipopolysaccharide-induced inflammation in BV-2 microglial cells.
Keyphrases
- lipopolysaccharide induced
- inflammatory response
- induced apoptosis
- molecular dynamics
- high resolution
- oxidative stress
- cell cycle arrest
- molecular docking
- lps induced
- density functional theory
- molecular dynamics simulations
- magnetic resonance imaging
- endoplasmic reticulum stress
- cell proliferation
- spinal cord injury
- dual energy
- computed tomography
- signaling pathway