The SCF/KIT axis in human mast cells: Capicua acts as potent KIT repressor and ERK predominates PI3K.

Kristin Franke Marieluise Kirchner Philipp Mertins Torsten Zuberbier Magda Babina

Published in: Allergy (2022)

The SCF/KIT axis shows notable strength in MCs, and MEK/ERK as most prominent module. An inhibitory circuit exists between KIT and CIC. CIC stabilization in MCs may turn out as a therapeutic option to interfere with allergic and MC-driven diseases.

Keyphrases

pi k akt
signaling pathway
cell proliferation
endothelial cells
fluorescent probe
living cells