Comparative whole transcriptome analysis of Parkinson's disease focusing on the efficacy of zonisamide.

Tatsuhiko NaitoWataru SatakePei-Chieng ChaKazuhiro KobayashiMiho MurataTatsushi Toda

Published in: Journal of neurology, neurosurgery, and psychiatry (2022)

Our results suggest that the efficacy of zonisamide in PD patients is associated with glutamate-related synaptic modulation and p53-mediated dopaminergic neural loss. Their transcriptomic differences could be captured before treatment, which would lead to the realisation of future personalised treatment.

Keyphrases

end stage renal disease
chronic kidney disease
newly diagnosed
peritoneal dialysis
combination therapy