Altered redox status may contribute to aberrant folliculogenesis and poor reproductive outcomes in women with polycystic ovary syndrome.

Aalaap A Naigaonkar Roshan Dadachanji Indira Hinduja Srabani Mukherjee

Published in: Journal of assisted reproduction and genetics (2021)

Our data indicates disrupted redox homeostasis in follicular environment in PCOS which may negatively influence oocyte/embryo quality. Further, granulosa cells may play crucial role in maintaining follicular redox homeostasis. Glutathione system and paraoxonase1 could be explored further as surrogates for IVF prognosis/outcome.

Keyphrases

polycystic ovary syndrome
pregnancy outcomes
induced apoptosis
insulin resistance
cell cycle arrest
electron transfer
electronic health record
pregnant women
big data
oxidative stress
endoplasmic reticulum stress
machine learning
cell death
signaling pathway
skeletal muscle
functional connectivity