Untargeted metabolomics identifies metabolic dysregulation of sphingolipids associated with aggressive chronic lymphocytic leukaemia and poor survival.

Flora Nguyen Van LongDélya Valcourt-GendronPatrick CaronMichèle RouleauLyne VilleneuveDavid SimonyanTrang LeRoxanne SergerieIsabelle LaverdièreKatrina VanuraChantal Guillemette

Published in: Clinical and translational medicine (2023)

Specific sphingolipids may serve as prognostic markers in CLL, and inhibiting enzymatic pathways involved in their biosynthesis has potential as a therapaeutic approach.

Keyphrases

mass spectrometry
genome wide
signaling pathway
liquid chromatography
hydrogen peroxide
chronic lymphocytic leukemia
free survival
human health
gas chromatography mass spectrometry
dna methylation
gene expression
climate change
solid phase extraction