Inhibition of Nek2 by small molecules affects proteasome activity.
Lingyao MengKent CarpenterAlexis MollardHariprasad VankayalapatiSteven L WarnerSunil SharmaGuido TricotFenghuang ZhanDavid J BearssPublished in: BioMed research international (2014)
Nek2 plays a central role in proteasome-mediated cell cycle regulation and in conferring resistance to bortezomib in cancer cells. Taken together, our results introduce Nek2 as a therapeutic target in bortezomib-resistant multiple myeloma.