Sex Differences in Adiposity and Cardiovascular Diseases.
Haoyun LiDaniels KonjaLuyao WangYu WangPublished in: International journal of molecular sciences (2022)
Body fat distribution is a well-established predictor of adverse medical outcomes, independent of overall adiposity. Studying body fat distribution sheds insights into the causes of obesity and provides valuable information about the development of various comorbidities. Compared to total adiposity, body fat distribution is more closely associated with risks of cardiovascular diseases. The present review specifically focuses on the sexual dimorphism in body fat distribution, the biological clues, as well as the genetic traits that are distinct from overall obesity. Understanding the sex determinations on body fat distribution and adiposity will aid in the improvement of the prevention and treatment of cardiovascular diseases (CVD).
Keyphrases
- insulin resistance
- cardiovascular disease
- weight gain
- metabolic syndrome
- type diabetes
- weight loss
- healthcare
- adipose tissue
- high fat diet induced
- genome wide
- skeletal muscle
- emergency department
- mental health
- cardiovascular risk factors
- gene expression
- coronary artery disease
- health information
- combination therapy
- human health
- copy number
- drug induced