Release of endothelial activation markers in lungs of patients with malaria-associated acute respiratory distress syndrome.

Thao-Thy PhamChuchard PunsawadSupattra GlaharnSimon F De MeyerParnpen ViriyavejakulPhilippe E Van den Steen

Published in: Malaria journal (2019)

This study documents a high level of VWF and ANG-2, two endothelial activation markers in the oedematous alveoli of post-mortem lung sections of Thai patients with MA-ARDS. Decreased detection of VWF in the endothelial lining of blood vessels, in parallel with an increased presence of intravascular VWF staining suggests marked endothelial activation and Weibel-Palade body release in the lungs of patients with MA-ARDS.

Keyphrases

acute respiratory distress syndrome
extracorporeal membrane oxygenation
mechanical ventilation
endothelial cells
loop mediated isothermal amplification
sensitive detection