Leptomeningeal disease in histone-mutant gliomas.
Maria DiazSatshil RanaCarlos Eduardo Silva CorreiaAnne S ReinerAndrew L LinAlexandra M MillerMaya S GrahamSofia ChudskyTejus A BaleMarc RosenblumMatthias A KarajannisElena PentsovaPublished in: Neuro-oncology advances (2023)
In our cohort, 50% of patients developed LMD. Although further studies are needed, CSF ctDNA characterization may aid in identifying molecular tumor profiles in glioma patients with LMD, and neuroaxis imaging and CSF NGS should be considered for early LMD detection.