MicroRNA-193b impairs muscle growth in mouse models of type 2 diabetes by targeting the PDK1/Akt signalling pathway.

Shu YangGuangyan YangHan WuLin KangJiaqing XiangPeilin ZhengShanhu QiuZhen LiangYan LuLijing Jia

Published in: Diabetologia (2021)

Our results identified a previously unrecognised role of miR-193b in muscle function and mass that could be a potential therapeutic target for treating sarcopenia.

Keyphrases

skeletal muscle
type diabetes
mouse model
insulin resistance
signaling pathway
cell proliferation
cardiovascular disease
glycemic control
adipose tissue
human health
risk assessment
climate change