Humoral immune response and live-virus neutralization of the SARS-CoV-2 omicron (BA.1) variant after COVID-19 mRNA vaccination in children and young adults with chronic kidney disease.

Maximillian StichVeronica Di CristanzianoBurkhard Tönshoff Lutz Thorsten Weber Jörg Dötsch Marian Theodor RammerSusanne RiegerEva Heger Sven F Garbade Kathrin Burgmaier Louise Benning Claudius Speer Sandra HabbigSophie Haumann

Published in: Pediatric nephrology (Berlin, Germany) (2022)

A standard mRNA vaccine regimen in immunosuppressed children and adolescents with kidney disease elicits an attenuated humoral immune response with effective live virus neutralization against the omicron variant in approximately 10% of the patients, underlying the need for omicron-adapted vaccination. A higher resolution version of the Graphical abstract is available as Supplementary information.

Keyphrases

immune response
sars cov
end stage renal disease
chronic kidney disease
peritoneal dialysis
dendritic cells
ejection fraction
coronavirus disease
newly diagnosed
toll like receptor
respiratory syndrome coronavirus
young adults
prognostic factors
binding protein
social media