A Population Dynamic Energy Budget-Based Tumor Growth Inhibition Model for Etoposide Effects on Wistar Rats.

E M ToscaM C PigattoT Dalla CostaPaolo Magni

Published in: Pharmaceutical research (2019)

The DEB-based TGI model capabilities, up to now assessed only in mice, are fully confirmed in this study involving rats. Results suggest that well designed experiments combined with a mechanistic modeling approach could be extremely useful to understand drug effects and to describe all the dynamics characterizing in vivo tumor growth studies.

Keyphrases

emergency department
metabolic syndrome
high fat diet induced
insulin resistance
skeletal muscle
electronic health record