Pharmacodynamic Effect of mTOR Inhibition-based Immunosuppressive Therapy on T- and B-cell Subsets After Renal Transplantation.

Xinyi WeiSabine WeberDecheng YinIda AllabauerTilman Jobst-SchwanMichael WiesenerMario SchifferDiana DudziakChristian H K LehmannJoachim WoelfleAndré Hoerning

Published in: Transplantation direct (2024)

mTORi selectively inhibited p70S6K phosphorylation in select lymphocyte subtypes. Assessing p70S6K phosphorylation by phosphoflow cytometry may serve as an approach to understand cell subset specific effects of mTORi providing detailed pharmacodynamic information for individualizing immunosuppression.

Keyphrases

single cell
peripheral blood
protein kinase
cell therapy
cell proliferation
stem cells
health information
bone marrow