NanoSPECT imaging reveals the uptake of 123I-labeled oxidized low-density lipoprotein in the brown adipose tissue of mice via CD36.

Kento HosomiHidekazu KawashimaAtsushi NakanoAkemi KakinoYuko Okamatsu-OguraYuki YamashitaMai SasaokaDaisaku MasudaShizuya YamashitaChu-Huang ChenShunsuke YuzurihaHiroshi HosodaHidehiro IidaTatsuya Sawamura

Published in: Cardiovascular research (2022)

We show novel evidence for the CD36-mediated accumulation of oxLDL in BAT, suggesting that BAT may exert its anti-atherogenic effects by removing atherogenic LDL from the circulation.

Keyphrases

low density lipoprotein
adipose tissue
high resolution
nk cells
insulin resistance
high fat diet induced
high fat diet
pet imaging
type diabetes
computed tomography
photodynamic therapy
fluorescence imaging