Size-Based Effects of Anthropogenic Ultrafine Particles on Lysosomal TRPML1 Channel and Autophagy in Motoneuron-like Cells.

Silvia SapienzaValentina TedeschiBarbara ApicellaFrancesco PalestraCarmela RussoIlaria PiccialliAnna PannaccioneStefania LoffredoAgnese Secondo

Published in: International journal of molecular sciences (2022)

Restoring TRPML1 function by an antioxidant agent may be considered a protective mechanism able to reestablish autophagy flux in motor neurons exposed to nanoparticles.

Keyphrases

oxidative stress
cell death
endoplasmic reticulum stress
signaling pathway
spinal cord
particulate matter
anti inflammatory